Could High Cholesterol Protect Against Alzheimer’s?

A Closer Look

Cholesterol is usually seen as a cardiovascular risk, but when it comes to the brain, the story might be more complicated. Emerging research suggests that higher cholesterol levels in older adults may actually be linked to better cognitive function and a lower risk of Alzheimer’s disease.

The brain relies heavily on cholesterol for building cell membranes, supporting myelin (nerve insulation), and maintaining synaptic health. In fact, it contains about 25% of the body’s total cholesterol. Some studies now show that low cholesterol in late life may correlate with faster cognitive decline, while those with higher levels may experience more stable memory and thinking skills.

This is still a controversial area. High cholesterol in midlife remains a known risk factor for dementia, and the “protective” effect appears more relevant after age 65. There’s also ongoing debate about how cholesterol-lowering medications like statins might affect memory in some individuals.

What This Means for Mental Health

For psychiatrists and mental health providers, this research opens new conversations about metabolic health and the brain. Rather than one-size-fits-all targets, age, cognitive risk, and overall health should guide cholesterol management, especially in older adults.

Curious how nutrition and brain health connect? Contact our clinic to learn more about integrative approaches to mental wellness.